Mollify is an open source web-based file manager, built with PHP & GWT, that can control files hosted in a web server or hosting account.
It has a simple, intuitive & Ajaxed interface that also supports multiple languages.

The application is multi-user (users & user-groups) where a file-level access can be set.
File actions & directory actions can be completed quickly from context popup menus. It is also possible to download files/folders in zipped format.
Mollify can upload multiple files at once & enables to list the contents with sortable columns.
A unique feature offered is the ability to define aliases for folders in order to hide the real folder structure for security purposes.
The interface is totally customizable with CSS. Also, integration of the application with other products is possible as the frontend & backends are independent (they communicate with HTTP/JSON).
Website: http://www.jaervelae.com/mollify/
Demo: http://www.jaervelae.com/mollify/demo.php
Download: http://www.jaervelae.com/mollify/download.php

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